Use Ortelius’ slices to extract an area of your map as a completely new drawing.
Add a Slice
Extract Slice As New Document
With the Slice selected, choose ‘File > Extract Slice As New Document’. A new document will open containing all content contained within the slice. All settings for map scale, map area margins and drawing units from your original map are retained in your new drawing.
Drawing Setup and Reposition
Once you have created a new drawing, you may want to change the map size and reposition the content. Follow the steps you would during Drawing Setup, and Reposition as desired.